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Opana 40mg (Oxymorphone hydrochloride) is an opioid pain medication. An opioid is sometimes called a narcotic. Opana is used to treat moderate to severe pain.

The extended-release form of this medicine is for the around-the-clock treatment of severe pain. Opana ER is not for use on an as-needed basis for pain.

Opana may also be used for purposes not listed in this medication guide

Important information

You should not use Opana if you have severe asthma or breathing problems, a blockage in your stomach or intestines, or moderate to severe liver disease.

Oxymorphone can slow or stop your breathing, and may be habit-forming. MISUSE OF THIS MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.

Taking this medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.

Fatal side effects can occur if you use this medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.

Before using Opana 40mg (Oxymorphone hydrochloride)
You should not take Opana if you are allergic to oxymorphone, or if you have:
severe asthma or breathing problems;
a blockage in your stomach or intestines; or
moderate to severe liver disease.

To make sure Opana is safe for you, tell your doctor if you have ever had:
any type of breathing problem or lung disease;
head injury, brain tumor, or seizures;
drug or alcohol addiction, or mental illness;
urination problems;
liver or kidney problems; or
problems with your gallbladder, pancreas, or thyroid.

Some medicines can interact with oxymorphone and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take stimulant medicine, herbal products, or medicine for depression, mental illness, Parkinson’s disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.

If you use oxymorphone while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks.
It is not known whether oxymorphone passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breastfeeding a baby.

How should I use Opana 40mg (Oxymorphone hydrochloride)?

Take Opana exactly as prescribed. Follow all directions on your prescription label. Opana can slow or stop your breathing, especially when you start using this medicine or whenever your dose is changed. Never take Opana in larger amounts, or for longer than prescribed. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

What should I avoid?

Do not drink alcohol. Dangerous side effects or death could occur when alcohol is combined with oxymorphone. This medication may impair your thinking or reactions. Avoid driving or operating machinery until you know how Opana will affect you. Dizziness or severe drowsiness can cause falls or other accidents.

Opana side effects

Get emergency medical help if you have any signs of an allergic reaction to Opana: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Like other narcotic medicines, oxymorphone can slow your breathing. Death may occur if breathing becomes too weak.

A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue-colored lips, or if you are hard to wake up.

Call your doctor at once if you have:
weak or shallow breathing;
a light-headed feeling, like you, might pass out;
seizure (convulsions);
chest pain, wheezing, cough with yellow or green mucus;
severe vomiting; or
low cortisol levels – nausea, vomiting, loss of appetite, dizziness, worsening tiredness, or weakness.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. Serious side effects may be more likely in older adults and those who are malnourished or debilitated.

Long-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent.
Common Opana side effects may include:
stomach pain, nausea, vomiting, constipation, diarrhea;
dizziness, drowsiness, headache, tired feeling;
dry mouth increased sweating;
sleep problems (insomnia); or
mild rash or itching.

What other drugs will affect Opana 40mg (Oxymorphone hydrochloride)?

Narcotic (opioid) medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:

other narcotic medications – opioid pain medicine or prescription cough medicine;
a sedative like Valium – diazepam, alprazolam, lorazepam, Ativan, Klonopin, Restoril, Tranxene, Versed, Xanax.

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